Is this actually possible? In an overlooked study published in 2008 researchers compared a calorie restricted diet to a normal diet + the red wine molecule resveratrol or resveratrol + other small antioxidant molecules in laboratory mice. Mice have about the same number of genes (~25,000) as humans.
Life-long calorie restriction in a mouse activates ~832 genes. In a short-term 12-week study, the calorie-restricted diet significantly differentiated the activity of 198 genes and presumably would have altered 832 genes if practiced over a lifetime; plain resveratrol altered 225 genes and strikingly the resveratrol + other antioxidants (Longevinex®) 1711 genes. [Experimental Gerontology Sept 2008]
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